Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue.
نویسندگان
چکیده
A near-infrared fluorescent probe based on methylene blue (p-NBMB) was developed for the detection of nitroreductase. Conjugating methylene blue with a p-nitrobenzyl moiety enables it to be activated by nitroreductase-catalyzed 1,6-elimination, resulting in the release of an active methylene blue fluorophore.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 64 شماره
صفحات -
تاریخ انتشار 2015